Sec24a | SEC24 homolog A, COPII coat complex component

GeneMGI:1924621Synonyms: 9430090N21Rik

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Skeleton

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased body weight	3 supporting datasets	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.17x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.21x10^-12
decreased circulating cholesterol level	1 supporting dataset	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.62x10^-10
decreased circulating HDL cholesterol level	1 supporting dataset	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.08x10^-9
increased bone mineral density	1 supporting dataset	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.34x10^-5
increased lactate dehydrogenase level	1 supporting dataset	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.08x10^-5
increased blood urea nitrogen level	1 supporting dataset	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.84x10^-5
decreased circulating LDL cholesterol level	1 supporting dataset	Sec24a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.23x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sec24a.

Associated images

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Histopathology

There is no histopathology data found for Sec24a.

IMPC related publications

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External links

No external links available for Sec24a.

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*Sec24a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sec24a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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