Coq6 | coenzyme Q6 monooxygenase
Physiological systems
22 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Mortality/aging
15 No significant impact
2 Not tested
Data collections
Gene metrics:11Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| embryonic growth retardation | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.59x10-6 | ||
| abnormal tail bud morphology | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Coq6tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| abnormal cornea morphology | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.91x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.56x10-7 | ||
| increased circulating sodium level | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.68x10-9 | ||
| abnormal embryo size | 1 supporting dataset | Coq6tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Coq6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Coq6.
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| Coq6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Coq6tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Coq6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |