Ankrd11 | ankyrin repeat domain 11
Physiological systems
23 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Hearing/vestibular/ear Vision/eye Nervous system Behavior/neurological Skeleton Mortality/aging Cardiovascular system
13 No significant impact
1 Not tested
Data collections
Gene metrics:15Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
21Embryo tissues
| abnormal auditory brainstem response | 4 supporting datasets | Ankrd11tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.1x10-12 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ankrd11tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased prepulse inhibition | 1 supporting dataset | Ankrd11tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.55x10-6 | ||
| abnormal retina vasculature morphology | 2 supporting datasets | Ankrd11Yod | heterozygote | Early adult | 1.43x10-5 | ||
| abnormal head morphology | 2 supporting datasets | Ankrd11Yod | heterozygote | Early adult | 9.55x10-6 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Ankrd11tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.46x10-5 | ||
| abnormal response to new environment | 1 supporting dataset | Ankrd11Yod | heterozygote | Early adult | 6.52x10-5 | ||
| decreased body length | 1 supporting dataset | Ankrd11tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.69x10-7 | ||
| decreased startle reflex | 1 supporting dataset | Ankrd11tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.25x10-7 | ||
| increased circulating cholesterol level | 1 supporting dataset | Ankrd11tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.62x10-6 |
| | | | | | | | | | |
Human diseases caused by Ankrd11 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ankrd11.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ankrd11tm1(IMPC)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Ankrd11tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ankrd11tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ankrd11tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |