Cep83 | centrosomal protein 83
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Mortality/aging Cardiovascular system
14 No significant impact
5 Not tested
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| abnormal embryo size | 1 supporting dataset | Cep83tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Cep83tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Cep83tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Cep83tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| abnormal pericardium morphology | 1 supporting dataset | Cep83tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| edema | 1 supporting dataset | Cep83tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Cep83 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cep83.
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| Cep83tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Cep83tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Cep83tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cep83tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |