Rab36 | RAB36, member RAS oncogene family
GeneMGI:1924127
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Cardiovascular system
13 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| abnormal head morphology | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 1.77x10-5 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 6.27x10-5 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 6.27x10-5 | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 2.47x10-5 | ||
| increased heart weight | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 3.84x10-5 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 8.13x10-5 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 4.08x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Rab36tm1b(KOMP)Wtsi | homozygote | Early adult | 3.39x10-6 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Rab36 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rab36.
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| Rab36tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rab36tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |