Kdm4c | lysine (K)-specific demethylase 4C

GeneMGI:1924054Synonyms: 2410141F18Rik, Jmjd2c

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Hematopoietic system Skeleton

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased hematocrit	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.84x10^-8
increased bone mineral density	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.26x10^-5
increased B cell number	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.47x10^-5
decreased granulocyte number	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	9.65x10^-5
decreased hemoglobin content	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.9x10^-8
decreased lactate dehydrogenase level	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.51x10^-6
increased lean body mass	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.63x10^-5
increased circulating calcium level	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	9.86x10^-7
abnormal coat/hair pigmentation	1 supporting dataset	Kdm4c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.41x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kdm4c.

Associated images

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Histopathology

There is no histopathology data found for Kdm4c.

IMPC related publications

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External links

No external links available for Kdm4c.

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*Kdm4c^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Kdm4c^{tm1.1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	ES Cell
*Kdm4c^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Kdm4c^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Kdm4c^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Kdm4c^{tm360436(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Kdm4c^{tm36279(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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