Hectd3 | HECT domain E3 ubiquitin protein ligase 3

GeneMGI:1923858Synonyms: 1700064K09Rik

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Muscle Hematopoietic system Cardiovascular system Nervous system Liver/biliary system Respiratory system Behavior/neurological Skeleton

7 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small lung	2 supporting datasets	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	4.26x10^-9
small stomach	2 supporting datasets	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	8.12x10^-16
decreased grip strength	2 supporting datasets	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	4.67x10^-11
decreased bone mineral density	1 supporting dataset	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	1.09x10^-20
small spleen	2 supporting datasets	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	N/A ^*
small thymus	2 supporting datasets	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	N/A ^*
small heart	2 supporting datasets	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	N/A ^*
female infertility	1 supporting dataset	Hectd3^{tm1(NCOM)Cmhd}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hectd3.

Associated images

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Histopathology

There is no histopathology data found for Hectd3.

IMPC related publications

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External links

No external links available for Hectd3.

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*Hectd3^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse

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