Commd9 | COMM domain containing 9
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging
13 No significant impact
5 Not tested
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased hemoglobin content | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.41x10-6 | ||
| increased neutrophil cell number | 2 supporting datasets | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.94x10-8 | ||
| abnormal iris morphology | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 8.1x10-5 | ||
| impaired glucose tolerance | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 3.12x10-5 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.15x10-7 | ||
| decreased locomotor activity | 5 supporting datasets | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.3x10-6 | ||
| decreased circulating fructosamine level | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.88x10-6 | ||
| increased red blood cell distribution width | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 8.69x10-5 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.02x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Commd9tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Commd9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Commd9.
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| Commd9tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Commd9tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Commd9tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Commd9tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Commd9tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |