Ift43 | intraflagellar transport 43

GeneMGI:1923661Synonyms: 1700019E19Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Nervous system Cardiovascular system Mortality/aging Craniofacial

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

4Associated diseases

Expression examined in:50Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating cholesterol level	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.81x10^-8
increased circulating creatinine level	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.6x10^-11
abnormal neural tube closure	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal forebrain development	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Ift43^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal embryo turning	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
increased circulating total protein level	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.37x10^-5
abnormal neural tube morphology	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal pharyngeal arch morphology	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal heart morphology	1 supporting dataset	Ift43^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ift43.

Associated images

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Histopathology

There is no histopathology data found for Ift43.

IMPC related publications

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External links

No external links available for Ift43.

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*Ift43^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Ift43^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ift43^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ift43^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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