Ift43 | intraflagellar transport 43
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Nervous system Cardiovascular system Mortality/aging Craniofacial
14 No significant impact
4 Not tested
Data collections
Gene metrics:16Significant phenotypes
4Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
| increased circulating cholesterol level | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.81x10-8 | ||
| increased circulating creatinine level | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.6x10-11 | ||
| abnormal neural tube closure | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ift43tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| increased circulating total protein level | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.37x10-5 | ||
| abnormal neural tube morphology | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Ift43tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | n/a | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Ift43 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ift43.
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| Ift43tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ift43tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ift43tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ift43tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |