Sun5 | Sad1 and UNC84 domain containing 5

GeneMGI:1923657Synonyms: 1700021O15Rik, Spag4l

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system

11 No significant impact

4 Not tested

Gene metrics:12Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating calcium level1 supporting datasetSun5em1(IMPC)MbphomozygoteEarly adult1.27x10-5 
enlarged spleen1 supporting datasetSun5em1(IMPC)MbphomozygoteLate adultN/A * 
male infertility1 supporting datasetSun5em1(IMPC)MbphomozygoteEarly adultN/A * 
enlarged lymph nodes2 supporting datasetsSun5em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal liver morphology1 supporting datasetSun5em1(IMPC)MbphomozygoteLate adultN/A * 
abnormal spleen morphology1 supporting datasetSun5em1(IMPC)MbphomozygoteLate adultN/A * 
abnormal lymph node morphology2 supporting datasetsSun5em1(IMPC)MbphomozygoteEarly adultN/A * 
thrombocytopenia1 supporting datasetSun5em1(IMPC)MbphomozygoteLate adult1.8x10-5 
abnormal testis morphology1 supporting datasetSun5em1(IMPC)MbphomozygoteLate adultN/A * 
prolonged QT interval1 supporting datasetSun5em1(IMPC)MbphomozygoteLate adult1.81x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sun5em1(IMPC)MbpExon Deletionmouse
Sun5tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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