Zdhhc5 | zinc finger, DHHC domain containing 5
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
13 No significant impact
3 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| polycystic kidney | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased total retina thickness | 2 supporting datasets | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 5.53x10-12 | ||
| decreased startle reflex | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 6.92x10-6 | ||
| decreased total body fat amount | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 9.76x10-5 | ||
| shortened PR interval | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 2.3x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 5.74x10-5 | ||
| increased mean platelet volume | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 1.55x10-15 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 7.14x10-7 | ||
| abnormal retina morphology | 1 supporting dataset | Zdhhc5tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | 3.93x10-12 |
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Human diseases caused by Zdhhc5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zdhhc5.
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| Zdhhc5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zdhhc5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell mouse |
| Zdhhc5tm1e.1(EUCOMM)Hmgu | Promoter excision from Targeted, non-conditional allele | | mouse |
| Zdhhc5tm39351(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |