Stx16 | syntaxin 16
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Behavior/neurological Skeleton
14 No significant impact
6 Not tested
Data collections
Gene metrics:14Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
25Embryo tissues
| increased circulating alkaline phosphatase level | 1 supporting dataset | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 4.2x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 4.17x10-7 | ||
| hyperactivity | 8 supporting datasets | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 2.19x10-11 | ||
| increased circulating potassium level | 1 supporting dataset | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 1.02x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 5.39x10-5 | ||
| increased exploration in new environment | 1 supporting dataset | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 1.48x10-8 | ||
| increased lean body mass | 2 supporting datasets | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 2.66x10-7 | ||
| decreased thigmotaxis | 2 supporting datasets | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 1.14x10-8 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 7.1x10-6 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Stx16tm1b(KOMP)Wtsi | homozygote | Early adult | 2.51x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
Human diseases caused by Stx16 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Stx16.
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| Stx16tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Stx16tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Stx16tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Stx16tm301848(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |