Gpsm2 | G-protein signalling modulator 2 (AGS3-like, C. elegans)

GeneMGI:1923373Synonyms: Pins, LGN, +1 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Vision/eye Hematopoietic system Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased mean platelet volume1 supporting datasetGpsm2tm1b(EUCOMM)WtsiheterozygoteEarly adult7.37x10-7 
preweaning lethality, incomplete penetrance1 supporting datasetGpsm2tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal lens morphology1 supporting datasetGpsm2tm1b(EUCOMM)WtsiheterozygoteEarly adult1.87x10-10 
cataract1 supporting datasetGpsm2tm1b(EUCOMM)WtsiheterozygoteEarly adult8.01x10-10 
abnormal retina morphology1 supporting datasetGpsm2tm1b(EUCOMM)WtsiheterozygoteEarly adult5.86x10-7 
abnormal vitreous body morphology1 supporting datasetGpsm2tm1b(EUCOMM)WtsiheterozygoteEarly adult5.35x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Gpsm2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Gpsm2tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Gpsm2tm403(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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