Zmym2 | zinc finger, MYM-type 2
Physiological systems
19 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Embryo Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system
8 No significant impact
5 Not tested
Data collections
Gene metrics:19Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased leukocyte cell number | 1 supporting dataset | Zmym2em1(IMPC)J | heterozygote | Early adult | 1.25x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Zmym2em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal retina outer nuclear layer morphology | 2 supporting datasets | Zmym2em1(IMPC)Bay | heterozygote | Early adult | 2.67x10-5 | ||
| abnormal hindbrain development | 1 supporting dataset | Zmym2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Zmym2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal somite shape | 1 supporting dataset | Zmym2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| increased total body fat amount | 2 supporting datasets | Zmym2em1(IMPC)J | heterozygote | Early adult | 1.17x10-5 | ||
| increased startle reflex | 1 supporting dataset | Zmym2em1(IMPC)J | heterozygote | Early adult | 1.77x10-6 | ||
| increased exploration in new environment | 1 supporting dataset | Zmym2em1(IMPC)J | heterozygote | Early adult | 9.26x10-5 | ||
| abnormal heart morphology | 1 supporting dataset | Zmym2em1(IMPC)Bay | homozygote | E9.5 | N/A * |
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Human diseases caused by Zmym2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zmym2.
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| Zmym2em1(IMPC)Bay | Exon Deletion | | mouse |
| Zmym2em1(IMPC)J | Exon Deletion | | mouse |
| Zmym2tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Zmym2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zmym2tm449824(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |