Fbxw8 | F-box and WD-40 domain protein 8

GeneMGI:1923041Synonyms: FBW8, FBXO29, +3 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Fbxw8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased eosinophil cell number	2 supporting datasets	Fbxw8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.4x10^-21
increased blood urea nitrogen level	1 supporting dataset	Fbxw8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.21x10^-6
increased neutrophil cell number	1 supporting dataset	Fbxw8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.93x10^-6
decreased lymphocyte cell number	1 supporting dataset	Fbxw8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.61x10^-7
increased basophil cell number	2 supporting datasets	Fbxw8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.92x10^-19
increased circulating creatinine level	1 supporting dataset	Fbxw8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxw8.

Associated images

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Histopathology

There is no histopathology data found for Fbxw8.

IMPC related publications

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External links

No external links available for Fbxw8.

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*Fbxw8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fbxw8^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fbxw8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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