Cul5 | cullin 5
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Integument Embryo Growth/size/body region Nervous system Hematopoietic system Mortality/aging Cardiovascular system
14 No significant impact
2 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased spleen weight | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.34x10-6 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Cul5tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| pallor | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal pericardium morphology | 1 supporting dataset | Cul5tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 50% (1/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
Human diseases caused by Cul5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cul5.
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