Cul5 | cullin 5

GeneMGI:1922967Synonyms: 4921514I20Rik, C030032G03Rik, +3 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Immune system Integument Embryo Growth/size/body region Nervous system Hematopoietic system Mortality/aging Cardiovascular system

14 No significant impact

2 Not tested

Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

increased spleen weight1 supporting datasetCul5tm1.1(KOMP)VlcgheterozygoteEarly adult3.34x10-6 
preweaning lethality, complete penetrance3 supporting datasetsCul5tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetCul5tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
embryonic growth retardation1 supporting datasetCul5tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
embryonic lethality prior to tooth bud stage1 supporting datasetCul5tm1.1(KOMP)VlcghomozygoteE12.5N/A * 
abnormal neural tube morphology1 supporting datasetCul5tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
abnormal spleen morphology1 supporting datasetCul5tm1.1(KOMP)VlcgheterozygoteEarly adultN/A * 
enlarged spleen1 supporting datasetCul5tm1.1(KOMP)VlcgheterozygoteEarly adultN/A * 
pallor1 supporting datasetCul5tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
abnormal pericardium morphology1 supporting datasetCul5tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cul5tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Cul5tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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