Ippk | inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Embryo Growth/size/body region Mortality/aging
16 No significant impact
5 Not tested
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| embryonic growth retardation | 1 supporting dataset | Ippktm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Ippktm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ippktm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ippktm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Ippktm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ippktm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (1/1) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Ippk mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ippk.
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| Ippktm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ippktm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ippktm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ippktm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |