Timmdc1 | translocase of inner mitochondrial membrane domain containing 1

GeneMGI:1922139Synonyms: 4930455C21Rik, 2810021C21Rik

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Mortality/aging

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat appearance4 supporting datasetsTimmdc1tm1b(EUCOMM)WtsiheterozygoteEarly adult6.82x10-6 
preweaning lethality, complete penetrance1 supporting datasetTimmdc1tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased circulating alanine transaminase level1 supporting datasetTimmdc1tm1b(EUCOMM)WtsiheterozygoteEarly adult8.56x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Timmdc1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Timmdc1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Timmdc1tm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Timmdc1tm46124(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Timmdc1tm46124(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Timmdc1tm46124(L1L2_gt2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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