Fbf1 | Fas binding factor 1
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton
11 No significant impact
6 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating serum albumin level | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.79x10-6 | ||
| decreased lean body mass | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.88x10-7 | ||
| increased total body fat amount | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.99x10-12 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.9x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.99x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.47x10-7 | ||
| increased leukocyte cell number | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.88x10-5 | ||
| abnormal bone structure | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.13x10-6 | ||
| decreased bone mineral content | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.77x10-12 | ||
| abnormal humerus morphology | 1 supporting dataset | Fbf1tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.54x10-7 |
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Human diseases caused by Fbf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fbf1.
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| Fbf1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Fbf1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |