Fbf1 | Fas binding factor 1

GeneMGI:1922033Synonyms: 1110033G01Rik

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating serum albumin level	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.79x10^-6
decreased lean body mass	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.88x10^-7
increased total body fat amount	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.99x10^-12
decreased circulating cholesterol level	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.9x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.99x10^-5
increased fasting circulating glucose level	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.47x10^-7
increased leukocyte cell number	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.88x10^-5
abnormal bone structure	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.13x10^-6
decreased bone mineral content	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.77x10^-12
abnormal humerus morphology	1 supporting dataset	Fbf1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.54x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbf1.

Associated images

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Histopathology

There is no histopathology data found for Fbf1.

IMPC related publications

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External links

No external links available for Fbf1.

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*Fbf1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Fbf1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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