Tent5c | terminal nucleotidyltransferase 5C
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased grip strength | 2 supporting datasets | Tent5ctm1b(KOMP)Wtsi | heterozygote | Early adult | 7.92x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Tent5ctm1b(KOMP)Wtsi | heterozygote | Early adult | 2.39x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Tent5ctm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 50% (1/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 50% (1/2) | 0% (0/173) |
| bone | heterozygote | n/a | 50% (1/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (1/1) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 50% (1/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (1/1) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Tent5c mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tent5c.
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| Tent5ctm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tent5ctm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |