Mlkl | mixed lineage kinase domain-like
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Integument Growth/size/body region Hematopoietic system
18 No significant impact
2 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged spleen | 1 supporting dataset | Mlklem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Mlklem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Mlklem1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Mlkl mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mlkl.
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| Mlklem1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Mlkltm51108(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |