Zfp871 | zinc finger protein 871
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
15 No significant impact
3 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
| abnormal embryo size | 1 supporting dataset | Zfp871tm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| increased grip strength | 1 supporting dataset | Zfp871tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.51x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Zfp871tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Zfp871tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.88x10-7 | ||
| embryonic growth retardation | 1 supporting dataset | Zfp871tm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| decreased total retina thickness | 2 supporting datasets | Zfp871tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.2x10-7 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Zfp871tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.96x10-5 |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | Wholemount images | 100% (1/1) | 1.67% (7/419) |
Human diseases caused by Zfp871 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zfp871.
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| Zfp871tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Zfp871tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Zfp871tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |