Lrrc17 | leucine rich repeat containing 17
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
3 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged epididymis | 1 supporting dataset | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged heart | 2 supporting datasets | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal heart morphology | 2 supporting datasets | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased freezing behavior | 1 supporting dataset | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | 9.98x10-8 | ||
| abnormal spleen morphology | 2 supporting datasets | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal gallbladder morphology | 1 supporting dataset | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Lrrc17em1(IMPC)Ccpcz | homozygote | Early adult | 2.41x10-5 |
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Human diseases caused by Lrrc17 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Lrrc17.
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| Lrrc17em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Lrrc17tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Lrrc17tm1.1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | ES Cell |
| Lrrc17tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Lrrc17tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Lrrc17tm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Lrrc17tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Lrrc17tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |