Ap5m1 | adaptor-related protein complex 5, mu 1 subunit

GeneMGI:1921635Synonyms: 4932432K03Rik, Mudeng

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Behavior/neurological

16 No significant impact

4 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal lymph node morphology1 supporting datasetAp5m1em1(IMPC)MbphomozygoteEarly adultN/A * 
decreased locomotor activity2 supporting datasetsAp5m1em1(IMPC)MbphomozygoteEarly adult5.69x10-11 
increased circulating total protein level1 supporting datasetAp5m1em1(IMPC)MbphomozygoteEarly adult3.87x10-6 
abnormal skin morphology1 supporting datasetAp5m1em1(IMPC)MbphomozygoteEarly adultN/A * 
increased freezing behavior1 supporting datasetAp5m1em1(IMPC)MbphomozygoteEarly adult1.8x10-17 
increased circulating serum albumin level1 supporting datasetAp5m1em1(IMPC)MbphomozygoteEarly adult5.14x10-6 
enlarged lymph nodes1 supporting datasetAp5m1em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ap5m1em1(IMPC)MbpExon Deletionmouse
Ap5m1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ap5m1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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