Xrcc3 | X-ray repair complementing defective repair in Chinese hamster cells 3
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Hematopoietic system Mortality/aging
17 No significant impact
5 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:52Adult tissues
26Embryo tissues
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Xrcc3tm1b(KOMP)Mbp | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Xrcc3tm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| decreased mean corpuscular volume | 1 supporting dataset | Xrcc3tm1b(KOMP)Mbp | heterozygote | Early adult | 1.13x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Xrcc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Xrcc3.
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| Xrcc3tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Xrcc3tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Xrcc3tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |