Lonp1 | lon peptidase 1, mitochondrial

GeneMGI:1921392Synonyms: Prss15, 1200017E13Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Vision/eye Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal lens morphology	2 supporting datasets	Lonp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.09x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Lonp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Lonp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.87x10^-5
decreased circulating iron level	1 supporting dataset	Lonp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.01x10^-5
decreased prepulse inhibition	4 supporting datasets	Lonp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.14x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lonp1.

Associated images

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Histopathology

There is no histopathology data found for Lonp1.

IMPC related publications

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External links

No external links available for Lonp1.

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*Lonp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lonp1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Lonp1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lonp1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Lonp1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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