Traf3ip1 | TRAF3 interacting protein 1
Physiological systems
14 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Mortality/aging Cardiovascular system
8 No significant impact
10 Not tested
Data collections
Gene metrics:10Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E12.5 | N/A * | ||
| edema | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Traf3ip1em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal pericardium morphology | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal somite shape | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| increased cornea thickness | 1 supporting dataset | Traf3ip1em1(IMPC)Bay | heterozygote | Early adult | 2.63x10-5 |
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Human diseases caused by Traf3ip1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Traf3ip1.
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| Traf3ip1em1(IMPC)Bay | Exon Deletion | | mouse |
| Traf3ip1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Traf3ip1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |