Psmb11 | proteasome (prosome, macropain) subunit, beta type, 11

GeneMGI:1921152Synonyms: 5830406J20Rik, beta5t

Physiological systems

23 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Limbs/digits/tail Hematopoietic system Cardiovascular system

14 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal thymus morphology	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal ileum morphology	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased NK T cell number	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.05x10^-6
small testis	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.32x10^-21
enlarged heart	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased effector memory T-helper cell number	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.83x10^-5
increased T-helper cell number	1 supporting dataset	Psmb11^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.48x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Psmb11.

Associated images

16 images

X-ray

XRay Images Forepaw

32 images

X-ray

XRay Images Hind Leg and Hip

16 images

X-ray

XRay Images Skull Dorso Ventral Orientation

16 images

X-ray

XRay Images Skull Lateral Orientation

32 images

X-ray

XRay Images Whole Body Dorso Ventral

16 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Psmb11 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



‌	‌	‌	‌	‌

Download data as:

Histopathology

There is no histopathology data found for Psmb11.

IMPC related publications

Loading...

External links

No external links available for Psmb11.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Psmb11^{em1(IMPC)Ccpcz}*	Inter-exon deletion	‌	mouse

My Genes

Psmb11 | proteasome (prosome, macropain) subunit, beta type, 11

Physiological systems

9 Significantly impacted by the knock-out

14 No significant impact

1 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Psmb11 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data