Poldip3 | polymerase (DNA-directed), delta interacting protein 3
Physiological systems
10 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Skeleton Mortality/aging
7 No significant impact
14 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Poldip3em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 1 supporting dataset | Poldip3em1(IMPC)Bay | heterozygote | Early adult | 1.33x10-5 | ||
| increased cornea thickness | 1 supporting dataset | Poldip3em1(IMPC)Bay | heterozygote | Early adult | 3.21x10-5 |
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Human diseases caused by Poldip3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Poldip3.
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| Poldip3em1(IMPC)Bay | Exon Deletion | | mouse |
| Poldip3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Poldip3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |