Tmtc4 | transmembrane and tetratricopeptide repeat containing 4

GeneMGI:1921050Synonyms: 4930403J22Rik, 5730419O14Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Nervous system Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased prepulse inhibition	4 supporting datasets	Tmtc4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.18x10^-31
decreased startle reflex	1 supporting dataset	Tmtc4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.74x10^-5
abnormal auditory brainstem response	6 supporting datasets	Tmtc4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.22x10^-6
abnormal startle reflex	1 supporting dataset	Tmtc4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.79x10^-15
decreased fasting circulating glucose level	1 supporting dataset	Tmtc4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.96x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmtc4.

Associated images

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Histopathology

There is no histopathology data found for Tmtc4.

IMPC related publications

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External links

No external links available for Tmtc4.

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*Tmtc4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Tmtc4^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

My Genes