Ttc7 | tetratricopeptide repeat domain 7

GeneMGI:1920999Synonyms: 1700007L07Rik, hea, +2 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Pigmentation Integument Adipose tissue Growth/size/body region Behavior/neurological Mortality/aging

13 No significant impact

5 Not tested

Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal vocalization1 supporting datasetTtc7em1(IMPC)JheterozygoteEarly adult2.42x10-10 
decreased grip strength2 supporting datasetsTtc7em1(IMPC)JheterozygoteEarly adult2.94x10-8 
abnormal coat/ hair morphology1 supporting datasetTtc7em1(IMPC)JheterozygoteEarly adult2.21x10-5 
increased total body fat amount2 supporting datasetsTtc7em1(IMPC)JheterozygoteEarly adult1.58x10-6 
decreased lean body mass2 supporting datasetsTtc7em1(IMPC)JheterozygoteEarly adult2x10-6 
preweaning lethality, complete penetrance1 supporting datasetTtc7em1(IMPC)JhomozygoteEarly adultN/A * 
abnormal coat/hair pigmentation2 supporting datasetsTtc7em1(IMPC)JheterozygoteEarly adult4.02x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ttc7em1(IMPC)JExon Deletionmouse
Ttc7tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ttc7tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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