Ppp2r1b | protein phosphatase 2, regulatory subunit A, beta
Physiological systems
16 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Hematopoietic system Skeleton Craniofacial
9 No significant impact
8 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased basophil cell number | 2 supporting datasets | Ppp2r1btm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.36x10-20 | ||
| abnormal tooth morphology | 1 supporting dataset | Ppp2r1btm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.85x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Ppp2r1btm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.28x10-5 | ||
| increased eosinophil cell number | 2 supporting datasets | Ppp2r1btm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.06x10-11 | ||
| male infertility | 1 supporting dataset | Ppp2r1btm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Ppp2r1b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ppp2r1b.
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| Ppp2r1btm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ppp2r1btm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ppp2r1btm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |