Bloc1s2 | biogenesis of lysosomal organelles complex-1, subunit 2

GeneMGI:1920939Synonyms: Bloc1s2a, 2410089B13Rik, +2 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Limbs/digits/tail Liver/biliary system Hematopoietic system Craniofacial Mortality/aging Cardiovascular system

12 No significant impact

4 Not tested

Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues

Phenotypes

edema1 supporting datasetBloc1s2tm1.1(KOMP)MbphomozygoteE15.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetBloc1s2tm1.1(KOMP)MbphomozygoteEarly adultN/A * 
pale liver1 supporting datasetBloc1s2tm1.1(KOMP)MbphomozygoteE12.5N/A * 
abnormal pericardium morphology1 supporting datasetBloc1s2tm1.1(KOMP)MbphomozygoteE12.5N/A * 
abnormal limb bud morphology1 supporting datasetBloc1s2tm1.1(KOMP)MbphomozygoteE12.5N/A * 
hemorrhage1 supporting datasetBloc1s2tm1.1(KOMP)MbphomozygoteE15.5N/A * 
abnormal placenta size1 supporting datasetBloc1s2tm1.1(KOMP)MbphomozygoteE15.5N/A * 
thrombocytopenia1 supporting datasetBloc1s2tm1.1(KOMP)MbpheterozygoteEarly adult5.86x10-5 
decreased circulating free fatty acids level1 supporting datasetBloc1s2tm1.1(KOMP)MbpheterozygoteEarly adult5.23x10-6 
increased circulating alanine transaminase level1 supporting datasetBloc1s2tm1.1(KOMP)MbpheterozygoteEarly adult6.81x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  
Rows per page: 










* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

Loading...

Histopathology

IMPC related publications

Loading...

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

Bloc1s2tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
es cell
mouse
Bloc1s2tm1.1(KOMP)MbpReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Bloc1s2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter