Bloc1s2 | biogenesis of lysosomal organelles complex-1, subunit 2

GeneMGI:1920939Synonyms: Bloc1s2a, 2410089B13Rik, +2 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Limbs/digits/tail Liver/biliary system Hematopoietic system Craniofacial Mortality/aging Cardiovascular system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	N/A ^*
pale liver	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	homozygote	E12.5	N/A ^*
abnormal pericardium morphology	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	homozygote	E12.5	N/A ^*
abnormal limb bud morphology	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	homozygote	E12.5	N/A ^*
hemorrhage	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	homozygote	E15.5	N/A ^*
abnormal placenta size	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	homozygote	E15.5	N/A ^*
thrombocytopenia	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	heterozygote	Early adult	5.86x10^-5
decreased circulating free fatty acids level	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	heterozygote	Early adult	5.23x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Bloc1s2^{tm1.1(KOMP)Mbp}	heterozygote	Early adult	6.81x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bloc1s2.

Associated images

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Histopathology

There is no histopathology data found for Bloc1s2.

IMPC related publications

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External links

No external links available for Bloc1s2.

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*Bloc1s2^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell mouse
*Bloc1s2^{tm1.1(KOMP)Mbp}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Bloc1s2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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