Mipol1 | mirror-image polydactyly 1
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological Cardiovascular system
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| decreased locomotor activity | 1 supporting dataset | Mipol1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.64x10-5 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Mipol1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.8x10-5 | ||
| decreased prepulse inhibition | 3 supporting datasets | Mipol1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.82x10-7 | ||
| increased circulating lipase level | 1 supporting dataset | Mipol1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.39x10-5 | ||
| abnormal lens morphology | 2 supporting datasets | Mipol1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.26x10-6 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Mipol1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.77x10-9 | ||
| cataract | 1 supporting dataset | Mipol1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Mipol1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mipol1.
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| Mipol1tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Mipol1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mipol1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mipol1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |