Ptchd4 | patched domain containing 4
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Integument Growth/size/body region Limbs/digits/tail Respiratory system Cardiovascular system
17 No significant impact
2 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged heart | 1 supporting dataset | Ptchd4em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Ptchd4em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased lung elastance | 1 supporting dataset | Ptchd4em1(IMPC)Ccpcz | homozygote | Early adult | 7.31x10-5 | ||
| abnormal digit morphology | 1 supporting dataset | Ptchd4em1(IMPC)Ccpcz | homozygote | Early adult | 4.99x10-8 | ||
| abnormal heart morphology | 1 supporting dataset | Ptchd4em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Ptchd4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ptchd4.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ptchd4em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Ptchd4tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ptchd4tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |