Pcdh18 | protocadherin 18

GeneMGI:1920423Synonyms: PCDH68L

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Cardiovascular system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



persistence of hyaloid vascular system	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.92x10^-14
hyperactivity	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.66x10^-5
decreased thigmotaxis	2 supporting datasets	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.63x10^-5
increased lean body mass	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.91x10^-5
shortened QT interval	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.83x10^-5
decreased total body fat amount	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.33x10^-5
cornea opacity	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.4x10^-6
abnormal behavior	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.73x10^-5
syndactyly	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.74x10^-5
shortened ST segment	1 supporting dataset	Pcdh18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.44x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pcdh18.

Associated images

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Histopathology

There is no histopathology data found for Pcdh18.

IMPC related publications

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External links

No external links available for Pcdh18.

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*Pcdh18^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Pcdh18^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Pcdh18^{tm414480(Ifitm2_intron_L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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