Trmt10a | tRNA methyltransferase 10A

GeneMGI:1920421Synonyms: 3110023L08Rik, Rg9mtd2

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Skeleton

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased body weight	5 supporting datasets	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.3x10^-8
decreased circulating creatinine level	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.85x10^-5
abnormal lens morphology	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.97x10^-5
increased bone mineral content	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.4x10^-6
abnormal behavior	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.56x10^-5
cataract	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.26x10^-5
increased circulating free fatty acids level	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.11x10^-5
increased circulating magnesium level	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.59x10^-5
increased circulating triglyceride level	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.92x10^-6
increased bone mineral density	1 supporting dataset	Trmt10a^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.86x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trmt10a.

Associated images

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Histopathology

There is no histopathology data found for Trmt10a.

IMPC related publications

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External links

No external links available for Trmt10a.

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*Trmt10a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Trmt10a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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