Trmt10a | tRNA methyltransferase 10A
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Skeleton
14 No significant impact
5 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased body weight | 5 supporting datasets | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.3x10-8 | ||
| decreased circulating creatinine level | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.85x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.97x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.4x10-6 | ||
| abnormal behavior | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.56x10-5 | ||
| cataract | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.26x10-5 | ||
| increased circulating free fatty acids level | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.11x10-5 | ||
| increased circulating magnesium level | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.59x10-5 | ||
| increased circulating triglyceride level | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.92x10-6 | ||
| increased bone mineral density | 1 supporting dataset | Trmt10atm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.86x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/4) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Trmt10a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trmt10a.
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| Trmt10atm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Trmt10atm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |