Dact2 | dishevelled-binding antagonist of beta-catenin 2

GeneMGI:1920347Synonyms: Dpr2, Frd2, +2 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Integument Vision/eye Hematopoietic system Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal eye anterior chamber depth	1 supporting dataset	Dact2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.36x10^-8
abnormal spleen morphology	1 supporting dataset	Dact2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal skin coloration	1 supporting dataset	Dact2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.24x10^-5
abnormal coat/ hair morphology	1 supporting dataset	Dact2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.43x10^-8
preweaning lethality, incomplete penetrance	1 supporting dataset	Dact2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Dact2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.33x10^-6
abnormal skin morphology	1 supporting dataset	Dact2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.05x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dact2.

Associated images

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Histopathology

There is no histopathology data found for Dact2.

IMPC related publications

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External links

No external links available for Dact2.

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*Dact2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Dact2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dact2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dact2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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