Wdr11 | WD repeat domain 11

GeneMGI:1920230Synonyms: 2900055P10Rik, Brwd2, +1 more

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal tail length	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	Early adult	8.13x10^-5
abnormal kidney morphology	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
male infertility	1 supporting dataset	Wdr11^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Wdr11^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	Early adult	1.29x10^-5
improved glucose tolerance	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	Late adult	3.93x10^-5
abnormal spinal cord morphology	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
small heart	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
no spontaneous movement	1 supporting dataset	Wdr11^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wdr11.

Associated images

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Histopathology

There is no histopathology data found for Wdr11.

IMPC related publications

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External links

No external links available for Wdr11.

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*Wdr11^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Wdr11^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Wdr11^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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