Lonrf2 | LON peptidase N-terminal domain and ring finger 2

GeneMGI:1920209Synonyms: 2900060P06Rik

Physiological systems

17 / 24 physiological systems tested

1 Significantly impacted by the knock-out

 Homeostasis/metabolism

16 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased fasting circulating glucose level1 supporting datasetLonrf2em2(IMPC)HhomozygoteLate adult5.6x10-5 
increased circulating calcium level1 supporting datasetLonrf2em2(IMPC)HhomozygoteLate adult1.3x10-5 
increased circulating creatinine level1 supporting datasetLonrf2em2(IMPC)HhomozygoteLate adult1.97x10-5 
impaired glucose tolerance1 supporting datasetLonrf2em2(IMPC)HhomozygoteLate adult1.42x10-5 
increased blood urea nitrogen level1 supporting datasetLonrf2em2(IMPC)HhomozygoteEarly adult2.17x10-15 
increased circulating creatinine level1 supporting datasetLonrf2em2(IMPC)HhomozygoteEarly adult8.76x10-5 
decreased circulating total protein level1 supporting datasetLonrf2em2(IMPC)HhomozygoteEarly adult3.45x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Lonrf2em1(IMPC)HExon Deletionmouse
Lonrf2em2(IMPC)HExon Deletionmouse
Lonrf2tm44982(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Lonrf2tm44982(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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