Ift25 | intraflagellar transport 25
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging
17 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 2 supporting datasets | Ift25tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating glycerol level | 1 supporting dataset | Ift25tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.23x10-5 | ||
| increased circulating free fatty acids level | 1 supporting dataset | Ift25tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 9.08x10-7 | ||
| increased circulating LDL cholesterol level | 1 supporting dataset | Ift25tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.21x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Ift25 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ift25.
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| Ift25tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ift25tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |