Ppp2r2b | protein phosphatase 2, regulatory subunit B, beta
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
14 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Ppp2r2btm1b(KOMP)Wtsi | homozygote | Early adult | 5.2x10-5 | ||
| increased circulating creatine kinase level | 1 supporting dataset | Ppp2r2btm1a(KOMP)Wtsi | homozygote | Early adult | 5.09x10-7 | ||
| decreased heart rate variability | 1 supporting dataset | Ppp2r2btm1b(KOMP)Wtsi | homozygote | Early adult | 5.19x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Ppp2r2btm1b(KOMP)Wtsi | homozygote | Early adult | 4.97x10-5 | ||
| increased leukocyte cell number | 1 supporting dataset | Ppp2r2btm1b(KOMP)Wtsi | homozygote | Early adult | 6.71x10-5 | ||
| hyperactivity | 7 supporting datasets | Ppp2r2btm1b(KOMP)Wtsi | homozygote | Early adult | 7.19x10-9 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Ppp2r2btm1a(KOMP)Wtsi | homozygote | Early adult | 1.11x10-5 | ||
| increased monocyte cell number | 1 supporting dataset | Ppp2r2btm1b(KOMP)Wtsi | homozygote | Early adult | 3.24x10-7 | ||
| thrombocytopenia | 1 supporting dataset | Ppp2r2btm1a(KOMP)Wtsi | homozygote | Early adult | 9.32x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Ppp2r2b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ppp2r2b.
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| Ppp2r2btm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ppp2r2btm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ppp2r2btm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ppp2r2btm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Ppp2r2btm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |