Ppp2r2b | protein phosphatase 2, regulatory subunit B, beta

GeneMGI:1920180Synonyms: E130009M08Rik, PP2A-PR55B, +4 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



abnormal retina morphology	1 supporting dataset	Ppp2r2b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.2x10^-5
increased circulating creatine kinase level	1 supporting dataset	Ppp2r2b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.09x10^-7
decreased heart rate variability	1 supporting dataset	Ppp2r2b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.19x10^-5
increased fasting circulating glucose level	1 supporting dataset	Ppp2r2b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.97x10^-5
increased leukocyte cell number	1 supporting dataset	Ppp2r2b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.71x10^-5
hyperactivity	7 supporting datasets	Ppp2r2b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.19x10^-9
decreased mean corpuscular hemoglobin	1 supporting dataset	Ppp2r2b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.11x10^-5
increased monocyte cell number	1 supporting dataset	Ppp2r2b^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.24x10^-7
thrombocytopenia	1 supporting dataset	Ppp2r2b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.32x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp2r2b.

Associated images

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Histopathology

There is no histopathology data found for Ppp2r2b.

IMPC related publications

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External links

No external links available for Ppp2r2b.

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*Ppp2r2b^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ppp2r2b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ppp2r2b^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ppp2r2b^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	es cell
*Ppp2r2b^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell

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