Macrod2 | mono-ADP ribosylhydrolase 2
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological
13 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
0Embryo tissues
| decreased thigmotaxis | 2 supporting datasets | Macrod2tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.69x10-5 | ||
| hyperactivity | 8 supporting datasets | Macrod2tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.99x10-13 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Macrod2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.82x10-8 | ||
| decreased circulating glucose level | 1 supporting dataset | Macrod2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9.52x10-6 | ||
| increased vertical activity | 1 supporting dataset | Macrod2tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.92x10-20 | ||
| hyperactivity | 2 supporting datasets | Macrod2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.93x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Macrod2tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.93x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Macrod2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.08x10-8 | ||
| increased hemoglobin content | 1 supporting dataset | Macrod2tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.4x10-5 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Macrod2tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.81x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Macrod2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Macrod2.
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