Setd5 | SET domain containing 5
Physiological systems
18 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Immune system Integument Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Mortality/aging Craniofacial
7 No significant impact
6 Not tested
Data collections
Gene metrics:14Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal tooth morphology | 1 supporting dataset | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.9x10-6 | ||
| abnormal coat/hair pigmentation | 2 supporting datasets | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.66x10-9 | ||
| decreased grip strength | 1 supporting dataset | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.49x10-5 | ||
| abnormal snout morphology | 2 supporting datasets | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.23x10-11 | ||
| abnormal auditory brainstem response | 3 supporting datasets | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.13x10-7 | ||
| increased regulatory T cell number | 1 supporting dataset | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| increased monocyte cell number | 1 supporting dataset | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| absent pinna reflex | 1 supporting dataset | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 9.77x10-6 | ||
| abnormal incisor morphology | 1 supporting dataset | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.43x10-6 | ||
| decreased circulating glucose level | 1 supporting dataset | Setd5tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7x10-5 |
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Human diseases caused by Setd5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Setd5.
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| Setd5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Setd5tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Setd5tm39685(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Setd5tm39685(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |