Csnk1g2 | casein kinase 1, gamma 2
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Muscle Hearing/vestibular/ear Vision/eye Respiratory system Hematopoietic system Cardiovascular system
12 No significant impact
5 Not tested
Data collections
Gene metrics:15Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased cardiac muscle contractility | 2 supporting datasets | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.62x10-5 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.9x10-7 | ||
| increased circulating phosphate level | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.83x10-5 | ||
| increased circulating potassium level | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.52x10-6 | ||
| increased pulmonary respiratory rate | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.46x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.71x10-15 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.77x10-5 | ||
| increased heart rate variability | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.52x10-7 | ||
| decreased total retina thickness | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.24x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Csnk1g2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.26x10-5 |
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Human diseases caused by Csnk1g2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Csnk1g2.
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| Csnk1g2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Csnk1g2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |