Fam117b | family with sequence similarity 117, member B

GeneMGI:1920000Synonyms: Als2cr13, 2810425F24Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Skeleton

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased bone mineral content	1 supporting dataset	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.25x10^-6
increased lean body mass	2 supporting datasets	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.29x10^-8
abnormal retina morphology	2 supporting datasets	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.36x10^-12
abnormal bone mineralization	1 supporting dataset	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.61x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.86x10^-7
increased bone mineral density	1 supporting dataset	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.53x10^-5
decreased circulating triglyceride level	1 supporting dataset	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.12x10^-6
decreased blood urea nitrogen level	1 supporting dataset	Fam117b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.38x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fam117b.

Associated images

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Histopathology

There is no histopathology data found for Fam117b.

IMPC related publications

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External links

No external links available for Fam117b.

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*Fam117b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fam117b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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