Skida1 | SKI/DACH domain containing 1
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Skeleton Mortality/aging
11 No significant impact
6 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:43Adult tissues
0Embryo tissues
| decreased erythrocyte cell number | 1 supporting dataset | Skida1tm1(KOMP)Wtsi | heterozygote | Early adult | 8.41x10-16 | ||
| enlarged lymph nodes | 2 supporting datasets | Skida1tm1.1(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Skida1tm1.1(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Skida1tm1.1(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Skida1tm1.1(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| decreased hemoglobin content | 1 supporting dataset | Skida1tm1(KOMP)Wtsi | heterozygote | Early adult | 6.84x10-14 | ||
| abnormal vertebral arch morphology | 1 supporting dataset | Skida1tm1(KOMP)Wtsi | heterozygote | Early adult | 1.62x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Skida1tm1(KOMP)Wtsi | heterozygote | Early adult | 8.92x10-5 | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Skida1tm1(KOMP)Wtsi | heterozygote | Early adult | 5.09x10-8 | ||
| decreased hematocrit | 1 supporting dataset | Skida1tm1(KOMP)Wtsi | heterozygote | Early adult | 1.08x10-17 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 50% (1/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
| eye | heterozygote | n/a | 0% (0/2) | 0% (0/335) |
Human diseases caused by Skida1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Skida1.
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| Skida1tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Skida1tm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |