Bbs5 | Bardet-Biedl syndrome 5

GeneMGI:1919819Synonyms: 2700023J09Rik, 1700049I01Rik

Physiological systems

19 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

9 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:28Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



tremors	1 supporting dataset	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.22x10^-5
increased hematocrit	1 supporting dataset	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.66x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.98x10^-36
increased circulating alanine transaminase level	1 supporting dataset	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.51x10^-23
short tibia	1 supporting dataset	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.01x10^-41
increased monocyte cell number	2 supporting datasets	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.75x10^-13
decreased respiratory quotient	1 supporting dataset	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.78x10^-12
decreased grip strength	3 supporting datasets	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.18x10^-19
decreased lean body mass	2 supporting datasets	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.8x10^-48
decreased bone mineral content	2 supporting datasets	Bbs5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.82x10^-75

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bbs5.

Associated images

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Histopathology

There is no histopathology data found for Bbs5.

IMPC related publications

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External links

No external links available for Bbs5.

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*Bbs5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Bbs5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Bbs5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Bbs5^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bbs5^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Bbs5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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