Smg1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase

GeneMGI:1919742Synonyms: 5430435M13Rik, C130002K18Rik, +2 more

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Mortality/aging

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetSmg1tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating bilirubin level1 supporting datasetSmg1tm1b(EUCOMM)HmguheterozygoteEarly adult2.48x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Smg1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Smg1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Smg1tm1a(NCOM)MfgcKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Smg1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Smg1tm299417(L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Smg1tm299418(L1L2_GT2_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Smg1tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell

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