Thoc1 | THO complex 1
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system
14 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased total body fat amount | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | 5.67x10-5 | ||
| abnormal heart morphology | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | homozygote | E9.5 | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased kidney weight | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | 1.48x10-7 | ||
| abnormal spleen morphology | 2 supporting datasets | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased mean corpuscular volume | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | 5.83x10-9 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | 1.47x10-7 | ||
| enlarged thymus | 1 supporting dataset | Thoc1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * |
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Human diseases caused by Thoc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Thoc1.
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| Thoc1em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Thoc1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Thoc1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Thoc1tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Thoc1tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |