Thoc1 | THO complex 1

GeneMGI:1919668Synonyms: NMP-84, 3110002N20Rik

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased total body fat amount	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	5.67x10^-5
abnormal heart morphology	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	homozygote	E9.5	N/A ^*
abnormal kidney morphology	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased kidney weight	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	1.48x10^-7
abnormal spleen morphology	2 supporting datasets	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	5.83x10^-9
increased mean corpuscular hemoglobin	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	1.47x10^-7
enlarged thymus	1 supporting dataset	Thoc1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Thoc1.

Associated images

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Histopathology

There is no histopathology data found for Thoc1.

IMPC related publications

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External links

No external links available for Thoc1.

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*Thoc1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Thoc1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Thoc1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Thoc1^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Thoc1^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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